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Toshiyuki Takahashi Selected Research

Aquaporin 4

1/2021Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders.
3/2020Repeated follow-up of AQP4-IgG titer by cell-based assay in neuromyelitis optica spectrum disorders (NMOSD).
10/2016Different etiologies and prognoses of optic neuritis in demyelinating diseases.
3/2015Anti-aquaporin 4 antibody-positive acute disseminated encephalomyelitis.
1/2015Markedly increased IP-10 production by blood-brain barrier in neuromyelitis optica.
9/2014Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders.
9/2014A case of pathology-proven neuromyelitis optica spectrum disorder with Sjögren syndrome manifesting aphasia and apraxia due to a localized cerebral white matter lesion.
4/2014Autocrine MMP-2/9 secretion increases the BBB permeability in neuromyelitis optica.
1/2014[A case of myelitis with anti-aquaporin 4 antibody concomitant with immune thrombocytopenic purpura].
1/2013Neuromyelitis optica preceded by hyperCKemia and a possible association with coxsackie virus group A10 infection.
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Toshiyuki Takahashi Research Topics

Disease

69Neuromyelitis Optica (Devic's Disease)
01/2022 - 05/2007
40Optic Neuritis (Retrobulbar Neuritis)
02/2022 - 01/2011
25Multiple Sclerosis
01/2022 - 02/2009
20Demyelinating Diseases (Demyelinating Disease)
05/2022 - 09/2010
18Encephalitis (Encephalitis, Rasmussen)
12/2022 - 11/2009
17Myelitis
12/2022 - 02/2008
14Neoplasms (Cancer)
01/2021 - 07/2003
12Acute Disseminated Encephalomyelitis (Postinfectious Encephalomyelitis)
01/2022 - 03/2015
12Myocardial Infarction
01/2015 - 03/2002
9Heart Failure
01/2021 - 01/2003
8Pain (Aches)
01/2021 - 09/2002
7Leukocytosis (Pleocytosis)
06/2020 - 05/2012
7Transverse Myelitis (Necrotizing Myelitis)
10/2019 - 02/2009
6Hypertension (High Blood Pressure)
01/2022 - 01/2007
6Spinal Cord Diseases
01/2021 - 04/2002
6Fibrosis (Cirrhosis)
02/2018 - 05/2003
6Ventricular Remodeling
01/2011 - 04/2003
6Infarction (Infarctions)
02/2009 - 01/2003
5Hypoxia (Hypoxemia)
01/2021 - 04/2005
5Disease Progression
01/2021 - 09/2011
5Infections
01/2018 - 01/2012
5Inflammation (Inflammations)
02/2014 - 05/2004
5Obesity
10/2012 - 01/2007
5Hypertrophy
02/2009 - 01/2003
4Kyphosis
06/2022 - 08/2016
4Nephrotic Syndrome (Syndrome, Nephrotic)
01/2022 - 01/2019
4Left Ventricular Dysfunction
01/2021 - 03/2005
4Autoimmune Diseases (Autoimmune Disease)
01/2020 - 02/2003
4Cognitive Dysfunction
05/2019 - 10/2012
4Cicatrix (Scar)
02/2018 - 02/2009
4Adenocarcinoma
12/2016 - 09/2003
4Disorders of Excessive Somnolence (Hypersomnia)
06/2015 - 08/2011
4Hemorrhage
01/2015 - 03/2002
4Necrosis
08/2011 - 02/2009
4Heart Rupture
12/2010 - 01/2003
4Body Weight (Weight, Body)
08/2009 - 07/2008
3Seizures (Absence Seizure)
12/2022 - 06/2020
3Hypesthesia (Numbness)
01/2022 - 09/2011
3Death (Near-Death Experience)
01/2021 - 02/2009
3Encephalomyelitis (Myeloencephalitis)
01/2020 - 08/2011
3Epilepsy (Aura)
11/2019 - 10/2018
3Opticospinal Multiple Sclerosis
12/2018 - 02/2009
3Central Nervous System Diseases (CNS Diseases)
11/2018 - 10/2015
3Coronary Artery Disease (Coronary Atherosclerosis)
11/2018 - 04/2013
3Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
12/2015 - 11/2009
3Carcinoma (Carcinomatosis)
05/2015 - 11/2008
3Unstable Angina
07/2013 - 09/2002
3Abdominal Aortic Aneurysm
10/2011 - 07/2011
3Hyperalgesia
01/2005 - 09/2002
3T-Cell Leukemia (Leukemia, T Cell)
06/2003 - 10/2002
2Proteinuria
11/2022 - 03/2007
2Relapsing-Remitting Multiple Sclerosis
05/2022 - 05/2016
2Intervertebral Disc Displacement (Herniated Disc)
01/2022 - 02/2018
2Atrophy
01/2022 - 12/2017
2Vision Disorders (Hemeralopia)
01/2022 - 06/2018

Drug/Important Bio-Agent (IBA)

45Myelin-Oligodendrocyte GlycoproteinIBA
12/2022 - 02/2014
39AntibodiesIBA
05/2022 - 02/2009
24Immunoglobulin G (IgG)IBA
03/2021 - 05/2007
17AutoantibodiesIBA
05/2021 - 02/2003
17Aquaporin 4IBA
01/2021 - 02/2009
16SteroidsIBA
11/2022 - 12/2003
13anti-aquaporin 4 autoantibodyIBA
04/2019 - 03/2009
10Proteins (Proteins, Gene)FDA Link
01/2020 - 02/2005
7Adrenal Cortex Hormones (Corticosteroids)IBA
10/2020 - 12/2003
7Messenger RNA (mRNA)IBA
01/2016 - 10/2004
7C-Reactive ProteinIBA
05/2013 - 01/2003
6CytokinesIBA
01/2021 - 04/2003
6Biomarkers (Surrogate Marker)IBA
10/2020 - 09/2010
6MethylprednisoloneFDA LinkGeneric
01/2020 - 05/2008
5Rituximab (Mabthera)FDA Link
01/2022 - 07/2011
5Glucose (Dextrose)FDA LinkGeneric
10/2019 - 04/2005
5Aquaporins (Water Channels)IBA
01/2018 - 05/2007
4Myelin Basic ProteinIBA
12/2022 - 05/2012
4Retinaldehyde (Retinal)IBA
01/2022 - 12/2010
4Prednisolone (Predate)FDA LinkGeneric
04/2021 - 12/2007
4Complement System Proteins (Complement)IBA
01/2021 - 03/2009
4Interleukin-6 (Interleukin 6)IBA
01/2021 - 12/2008
4AlbuminsIBA
01/2018 - 01/2007
4OrexinsIBA
06/2015 - 08/2011
4CollagenIBA
11/2011 - 02/2003
3Dimethyl FumarateIBA
05/2022 - 10/2019
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2022 - 10/2011
3salicylhydroxamic acid (SHAM)IBA
01/2022 - 01/2005
3CreatinineIBA
01/2021 - 01/2007
3Oligoclonal BandsIBA
09/2018 - 01/2011
3Insulin (Novolin)FDA Link
01/2015 - 07/2008
3Glial Fibrillary Acidic ProteinIBA
08/2014 - 05/2008
3AntigensIBA
09/2011 - 01/2006
3Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
08/2011 - 10/2008
3Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
03/2008 - 04/2005
3Biological ProductsIBA
01/2008 - 04/2005
3CalciumIBA
08/2006 - 01/2003
2Intravenous Immunoglobulins (IVIG)FDA Link
02/2022 - 01/2018

Therapy/Procedure

37Therapeutics
11/2022 - 03/2002
14Decompression
01/2022 - 04/2002
8Laminectomy
06/2022 - 03/2008
7Percutaneous Coronary Intervention
01/2021 - 11/2009
4Immunotherapy
06/2020 - 07/2003
4Conservative Treatment
11/2019 - 01/2011
3Catheters
01/2022 - 01/2014